Even today, 1 billion people do not have access to safe and affordable drinking water and perhaps twice that many lack adequate sanitation services.
In fact, inadequate drinking water quality is a leading cause of infant mortality worldwide.
Comparing the chromatographic behavior of native 1-deoxy SO to chemically synthesized SPH m18:1(14 Sphingolipids are typically formed by the condensation of serine and palmitoyl-Co A, a reaction catalyzed by the serine-palmitoyltransferase (SPT) enzyme.
Besides these canonical substrates, SPT can use other acyl-Co As, but also alanine or glycine, as substrates, which then form a category of atypical 1-deoxysphingolipids (1-deoxy SLs) that lack the C1-OH group of canonical sphingolipids (1, 2).
Moreover, the inadequacy of environmental water supplies in much of the world has been significantly exacerbated by declining trends in water quality.
Many developed countries have addressed this problem by adopting laws to guarantee supplies for the environment, but such guarantees are contingent on having adequate water for urban needs and on the availability of sufficient quantities of food.
The single biggest water problem worldwide is scarcity.This prevents its cleavage to hexadecenal by S1P-lyase, meaning that 1-deoxy SLs cannot be degraded by the canonical catabolic pathway (2).Apart from that, it was assumed that 1-deoxy SA is metabolized by the same set of enzymes as canonical sphingoid bases and that 1-deoxy SO, like sphingosine, bears a (4)(3OH) are structural isomers, probably differing in position and/or configuration of the carbon-carbon double bond.It attracted an audience of ≈100 that participated in wide-ranging discussions.The names of the water experts and the titles of their presentations are included on the NAS web site at
The 1-deoxysphinganine (1-deoxy SA), which is formed by SPT, can be converted to 1-deoxyceramides, but not to complex sphingolipids, because of the missing 1-OH group.